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奈多罗米  ≥95%

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包装规格：1mg 5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO（16.67mg/mL超声）
产品描述：基本信息 产品编号： N10995 产品名称： Nedocromil CAS: 69049-73-6   储存条件 粉末 -20℃ 四年     分子式： C19H17NO7 溶于液体 -80℃ 6个月 分子量： 371.34 -20℃ 1个月 化学名：  9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.6929mL 13.4647mL 26.9295mL 5mM 0.5386mL 2.6930mL 5.3859mL 10mM 0.2693mL 1.3465mL 2.6930mL   生物活性 产品描述 抑制多种介质的作用或形成，包括组胺，白三烯 C4 (LTC4) 和前列腺素 D2 (PGD2)。 靶点 LTC4 PGD Histamine   体外研究 Nedocromil inhibits the release of histamine,LTC4,and PGD2 from mast cells challenged with antigen (with IC30 values of 2.1μM,2.3μM,and 1.9μM,respectively) and with anti-human IgE (IC30 values of 4.7μM,1.3μM,and 1.3μM,respectively). 体内研究 Nedocromil-treated diabetic mice show significantly improved heart function compared with controls.The contractility and relaxation forces show similar improvements.However,the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice.Nedocromil can significantly improve cardiac function in mice with diabetic cardiomyopathy,but the treatment cannot restore normal function.   推荐实验方法(仅供参考) 动物实验:   Mice 8-12 weeks old C57/BL6 male mice between 23-25g receive intraperitoneal (i.p.) injections of 50mg/kg Streptozotocin (STZ),dissolved in 100mM citrate buffer pH 4.5,for five consecutive days.Diabetic mice (13-week-old) are randomly divided into three groups:1) untreated group;2) Nedocromil group,with Nedocromil released at the rate of 30mg/kg per day from a subcutaneous (s.c.) pellet implantation;and vehicle group,with an inactive pellet implanted.Normal mice (non-diabetic) and normal mice that receive Nedocromil (30mg/kg per day) are also included in this study for comparison.All sample groups included 15 mice (n=15).
保存条件：-20℃

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