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萝芙素盐酸盐  ≥98%

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包装规格：25mg 100mg in glass bottle
溶解性：溶于水（5mg/mL 超声），溶于DMSO（6mg/mL 超声）
产品描述：基本信息 产品编号： R10309 产品名称： Rauwolscine hydrochloride CAS: 6211-32-1   储存条件 粉末 -20℃ 四年     分子式： C21H27ClN2O3 溶于液体 -80℃ 6个月 分子量： 390.90 -20℃ 1个月 化学名：  Methyl (16beta,17alpha,20alpha)-17-hydroxyyohimban-16-carboxylate hydrochloride Solubility (25°C)：   体外:   DMSO 7mg/mL (17.9mM) Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.5582mL 12.7910mL 25.5820mL 5mM 0.5116mL 2.5582mL 5.1164mL 10mM 0.2558mL 1.2791mL 2.5582mL   生物活性 产品描述 一种高效，选择性的 α2 adrenergic 受体拮抗剂，Ki 值为12nM。 靶点 Ki:12nM (α2 adrenergic receptor)   体外研究 [3H]Rauwolscine binding to α2 adrenergic receptor is reversible,stcreospccific,and saturable.[3H]Rauwolscine specifically labels both the high and low affinity states of the α2 adrenergic receptor in brain membranes.[3H]Rauwolscine also behaves as a 5-HT1A receptor agonist and this conclusion is compatible with earlier functional studies, indicating that rauwolscine (as well as yohimbine) has agonistic properties at the level of 5-HT autoreceptors.When using [3H]5-HT as a radioligand,rauwolscine is determined to have relatively high affinity for the human receptor (Ki human=14.3nM,Ki rat=35.8nM).Saturation studies shows that the affinity of [3H]Rauwolscine is similar in mouse,rat,rabbit,dog (2.33-3.03nM) except man where it is significantly higher (0.98nM).   推荐实验方法(仅供参考) 激酶实验： Fresh bovine frontal cortex is incubated in triplicate with [3H]Rauwolscine (82 Ci/mM,diluted).Incubation is terminated by filtration under reduced pressure over filters,which are then rinsed with ice cold Tris-HCl buffer,dried overnight and added to disposable glass minivials containing 3.0mL of a 95% Econofluor/5% Protosol solution.Samples are counted by liquid scintillation spectrometry with an efficiency of 32%.(-)- [3H]Epinephrine binding to bovine cortex membranes is conducted at 25℃.
保存条件：-20℃

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