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Pentagamavunon-1  ≥98%

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包装规格：5mg 10mg 50mg 100mg in glass bottle
溶解性：溶于DMSO（50 mg/mL 超声）
产品描述：基本信息 产品编号：P10835 产品名称：Pentagamavunon-1 CAS: 27060-70-4   储存条件 粉末 -20℃ 四年     分子式： C23H24O3 溶于液体 -80℃ 六个月 分子量 348.43 -20℃ 一个月 化学名：      Solubility (25°C)   体外 DMSO   Ethanol   Water   体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.8700mL 14.3501mL 28.7002mL 5mM 0.5740mL 2.8700mL 5.7400mL 10mM 0.2870mL 1.4350mL 2.8700mL   生物活性 产品描述 是Curcumin 的类似物，具有口服活性，通过多个机制诱导凋亡信号，如抑制COX-2 和 VEGF。Pentagamavunon-1 (PGV-1) 可抑制 NF-κB 的激活。 靶点/IC50 Apoptosis;COX;VEGFR;NF-κB 体外研究 Pentagamavunon-1 (PGV-1, 1, 2.5, 5, 7.5, 10, 15, and 20µM) enhances cytotoxic effect of 5-FU on WiDr cells.Pentagamavunon-1 (PGV-1, 1,2.5,5,and 10µM) shows different effects on cell cycle progression and induces G2/M arrest.Cell Viability Assay Cell Line: Human colon carcinoma WiDr. Concentration: 1,2.5,5,7.5,10,15,and 20µM. Incubation Time: 6,12,24,and 48 hours. Result: Significantly enhanced the cytotoxicity of 5-FU on WiDr cells at various concentrations during 6,12,24,and 48h incubation. Cell Cycle Analysis Cell Line: WiDr cells Concentration: 1,2.5,5,and 10µM. Incubation Time: 24h.   Result: The non-treated WiDr cells showed cell accumulation in G1,S,and G2/M phase about 50.85%,36.11% and 13.04%,respectively. 体内研究 Pentagamavunon-1 (PGV-1, po, 20mg/kg) exhibits significant anti-tumor activity in PDX model,without obvious toxicity. Animal Model: Human cancer cells in a xenograf mouse model Dosage: 20mg/kg. Administration: P.O. every 2 days for 20 days. Result: Exhibited little decrease in body weight, nor a decrease in white and red blood cell counts in peripheral blood, nor any other efects in behavior and macroscopic appearance. Thus,PGV-1 was sufciently potent to suppress tumor formation in vivo, but exhibited little or no obvious adverse effects on the normal lineage of cells.
保存条件：-20℃

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