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AGN 194310  ≥98%

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包装规格：5mg in glass bottle
溶解性：溶于DMSO（50 mg/mL 超声）
产品描述：基本信息 产品编号： A11324 产品名称： AGN 194310 CAS: 229961-45-9   储存条件 粉末 -20℃ 四年     分子式： C28H24O2S 溶于液体 -80℃ 六个月 分子量 424.55 -20℃ 一个月 化学名：  4-((4-(4-ethylphenyl)-2,2-dimethyl-2H-thiochromen-6-yl)ethynyl)benzoic acid Solubility (25°C)：   体外:   DMSO 50mg/mL(117.77mM;Need ultrasonic) Ethanol   Water <0.1mg/mL(insoluble) 体内(现配现用): 1.请依序添加每种溶剂：10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility:≥2.5mg/mL(5.89mM);Clear solution 此⽅案可获得≥2.5mg/mL(5.89mM，饱和度未知)的澄清溶液。以1mL⼯作液为例，取100μL25.0mg/mL的澄清DMSO储备液加到400μL PEG300中，混合均匀；向上述体系中加⼊50μL Tween-80，混合均匀；然后继续加⼊450μL⽣理盐⽔定容⾄1mL。 2.请依序添加每种溶剂：10% DMSO→90% corn oil Solubility:≥2.5mg/mL(5.89mM);Clear solution 此⽅案可获得≥2.5mg/mL(5.89mM，饱和度未知)的澄清溶液，此⽅案不适⽤于实验周期在半个⽉以上的实验。以1mL⼯作液为例，取100μL25.0mg/mL的澄清DMSO储备液加到900μL⽟⽶油中，混合均匀。 ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.3554mL 11.7772mL 23.5544mL 5mM 0.4711mL 2.3554mL 4.7109mL 10mM 0.2355mL 1.1777mL 2.3554mL   生物活性 产品描述 一种高亲和力的、有效的、具有选择性的视黄酸受体(RARs)的泛拮抗剂，对RARα，RARβ，RARγ的Kd值分别为3nM，2nM，5nM。 靶点 RARα 3nM(Kd) RARβ 2nM(Kd) RARγ 5nM(Kd) 体外研究 AGN194310 potently inhibits colony formation by all three lines, with IC50 values of 16nM for LNCaP cells; 18nM for PC3 cells; and 34nM for DU-145 cells. AGN 194310 (50nM, 100nM; LNCaP, PC-3 and DU-145 cells) inhibits colony formation at concentrations of 50nM and 100nM alone and in combination with TTNPB. AGN 194310 (1μM; 72 hours; LNCaP cells) treatment results in 80% apoptosis Cell Viability Assay Cell Line: LNCaP, PC-3 and DU-145 cells. Concentration: 50nM, 100nM Incubation Time:   Result: When used together with 100nM TTNPB, there was almost complete reversal of the growth inhibitory effect of 50nM and partial reversal of the effect of 100nM. Apoptosis Analysis Cell Line: LNCaP cells Concentration: 1μM Incubation Time: 72 hours Result: Induced apoptosis in LNCaP cells. 体内研究 AGN 194310 (0.5mg/kg/day; oral gavage; every day; for 10 days; female C57Bl/6J mice) treatment increases the number of granulocytes across haemopoietic compartments. A significant increase in the frequency of granulocyte-progenitor cells is observed in the bone marrow of mice after treatment with AGN194310 Animal Model: Female C57Bl/6J mice (Five-week-old (34-37 days)) Dosage: 0.5mg/kg/day Administration: Oral gavage; every day; for 10 days Result: The number of granulocytes was significantly increased across haemopoietic compartments. Progenitor cells containing granulocytes also increased significantly.
保存条件：-20℃

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