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SW106065 促销  ≥98%

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包装规格：5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO（100 mg/mL 超声）
产品描述：基本信息 产品编号：S10725 产品名称：SW106065 CAS: 62289-81-0   储存条件 粉末 -20℃ 四年     分子式： C10H8N2Os 溶于液体 -80℃ 六个月 分子量 204.25 -20℃ 一个月 化学名：      Solubility (25°C)   体外 DMSO   Ethanol   Water   体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 4.8960mL 24.4798mL 48.9596mL 5mM 0.9792mL 4.8960mL 9.7919mL 10mM 0.4896mL 2.4480mL 4.8960mL   生物活性 产品描述 一种恶性周围神经鞘瘤 (MPNST) 的凋亡 (apoptosis) 诱导剂。 靶点/IC50 Apoptosis 体外研究 SW106065 (Compound 21, Cpd21) inhibits the human MPNST cell lines growth in a dose dependent manner, and EC50 concentrations of 439nM and 753.6nM for S462 and SNF96.2 cells,respectively. SW106065 remains nontoxic to normally dividing Schwann cells or mouse embryonic fibroblasts.SW106065 (Cpd21; 0.25-5µM; 24 hours; sMPNST cells) treatment shows a decreased percentage of cells in S phase, and a corresponding increased percentage in G1/G0 and G2/M.SW106065 (Cpd21;0.25-5µM; 24 hours; sMPNST cells) treatment decreases the levels of cyclin A2, cyclin B1, cyclin D1, cyclin E, cdk4, and cdk6. And increases levels of cdkn1a and cdkn2a mRNA were observed in a dose-dependent manner.SW106065 (Cpd21;0.25-5µM; 24 hours;sMPNST cells) treatment decreases the levels of Cyclin D1 protein.SW106065 (Cpd21) treatment significant increase in the percentage of apoptotic cells.Cell Cycle Analysis Cell Line: sMPNST cells Concentration: 0.25µM, 0.5µM, 1µM, 2.5µM, and 5µM Incubation Time: 24 hours Result: Showed a decreased percentage of cells in S phase, and a corresponding increased percentage in G1/G0 and G2/M. RT-PCR Cell Line: sMPNST cells Concentration: 0.25µM, 0.5µM, 1µM, 2.5µM, and 5µM Incubation Time: 24 hours Result: Decreased levels of cyclin A2, cyclin B1, cyclin D1, cyclin E, cdk4, and cdk6.Increased levels of cdkn1a and cdkn2a mRNA were observed in a dose-dependent manner. Western Blot Analysis Cell Line: sMPNST cells Concentration: 0.25µM, 0.5µM, 1µM, 2.5µM, and 5µM Incubation Time: 24 hours Result: Decreased levels of Cyclin D1 protein. 体内研究 SW106065 (Cpd21; 40mg/kg; intraperitoneal injection; twice per day for 4 weeks) treatment can be delivered to mice in concentrations to sufficiently penetrate sMPNST tissue, and inhibit tumor development. Animal Model: NCR-nu/nu female mice (6-7 week old) injected with MPNST cells Dosage: 40mg/kg Administration: Intraperitoneal injection; twice per day for 4 weeks Result: Reduced MPNST burden in a mouse allograft model.
保存条件：-20℃

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