生物试剂
>
生化试剂
>
信号通路
> MMAF
加入收藏 取消收藏

MMAF  98.85%

促销价¥{{model.attbuying.price}}

市场价¥0.00

累计销量0 累计评价0 人评论

别称 {{model.alias}}
中文名称 {{model.name}}
英文名称 {{model.enname}}
品牌 {{model.brand}}
CAS {{model.cas}}
分子式
分子量 {{model.molecularweight}}
MDL {{model.mdl}}
货号 {{model.procode}}
数量

+ -

件 库存{{model.attbuying.number}}件
立即购买 加入购物车 下载说明书

看了又看
包装规格：5mg 10mg 50mg 100mg in glass bottle
产品描述：基本信息 产品编号：M10685 产品名称：MMAF CAS: 745017-94-1   储存条件 粉末 -20℃ 四年 分子式： C39H65N5O8 溶于液体 -80℃ 六个月 分子量： 731.96     化学名：      Solubility (25°C)   体外 DMSO 100mg/mL (136.61mM) Ethanol 100mg/mL (136.61mM) Water 100mg/mL (136.61mM) 体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 1.3662mL 6.8310mL 13.6619mL 5mM 0.2732mL 1.3662mL 2.7324mL 10mM 0.1366mL 0.6831mL 1.3662mL 50mM 0.0273mL 0.1366mL 0.2732mL   生物活性 产品描述 一种有效的微管蛋白聚合抑制剂，用作抗肿瘤药物。 靶点/IC50 Auristatin   体外研究 MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC50s of 119, 105, 257 and 200nM in vitro cytotoxicity assay. 体内研究 The maximum tolerated dose in mice of MMAF (Monomethylauristatin F)(>16mg/kg) is much higher than MMAF (Monomethylauristatin F) (1mg/kg). cAC10-L1-MMAF4 has an MTD of 50mg/kg in mice and 15mg/kg in rats. The corresponding cAC10-L4-MMAF4 ADC was much less toxic, having MTDs in mice and rats of >150mg/ kg and 90 mg/kg in rats,respectively.   推荐实验方法(仅供参考) 细胞实验:   Cells are treated with serial dilutions of test molecules and incubated 4-6 days depending on cell line. Assessment of cellular growth and data reduction to generate IC50 values is done using Alamar Blue dye reduction assay.   动物实验:   Mice: When subcutaneous Karpas 299 tumor size reaches 300mm3,three animals per group receives one injection of 10mg antibody component/kg body weight of either cAC10-L1-MMAF4 or cBR96-L1-MMAF4 intravenously. Tumors are then removed and placed in optimal cutting temperature compound, and 5μm-thin frozen tissue sections are stained using immunohistochemistry evaluation.
保存条件：-20℃

猜你喜欢