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SCR7 pyrazine 促销  100%(HPLC)

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包装规格：5mg 25mg 100mg in glass bottle
溶解性：溶于DMSO(10mg/mL)
产品描述：基本信息 产品编号：S10075 产品名称：SCR7 pyrazine CAS: 14892-97-8   储存条件 粉末 -20℃ 四年     分子式： C18H12N4Os 溶于液体 -80℃ 两年 分子量 332.38 -20℃ 一个月 化学名：  2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone   Solubility (25°C)   体外 DMSO 100mg/mL (300.86mM; Need ultrasonic) Ethanol   Water   体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.0086mL 15.0430mL 30.0860mL 5mM 0.6017mL 3.0086mL 6.0172mL 10mM 0.3009mL 1.5043mL 3.0086mL   生物活性 产品描述 一种NHEJ(非同源末端连接)抑制剂，增强CRISPR-CAS9介导的同源定向修复。 靶点/IC50 DNA Ligase IV CRISPR/Cas9   体外研究 SCR7 pyrazine (20-100μM; 24 hours; MCF7 cells) treatment interferes with NHEJ in cells, leading to accumulation of unrepaired double-strand breaks (DSBs). SCR7 pyrazine treatment shows a dose-dependent decrease in cell proliferation with IC50 values of 40μM, 34μM, 44μM, 8.5μM, 120μM, 10μM and 50μM for MCF7, A549, HeLa, T47D, A2780, HT1080 and Nalm6 cells, respectively.In MCF7 cells, SCR7 pyrazine (20, 40μM) treatment increases phosphorylation of ATM and activates p53, decreases MDM2,BCL2, resulting in activation of proapoptotic proteins, PUMA and BAX. And the shorter fragments of MCL1, PARP1, Caspase 3,and Caspase 9 cleavage are upregulated in a dose-dependent manner. Western Blot Analysis Cell Line: MCF7 cells Concentration: 20μM, 40μM, 100μM Incubation Time: 24 hours Result: Showed an increase in levels of gH2AX foci and protein.   体内研究 SCR7 pyrazine (10 mg/kg; intraperitoneal injection; six doses; BALB/c mice) treatment significantly reduces breast adenocarcinoma-induced tumor and increases lifespan . Animal Model: BALB/c mice injected with breast adenocarcinoma cells Dosage: 10mg/kg Administration: Intraperitoneal injection; on alternate days (0, 2, 4, 6, 8, and 10) Result: Significantly reduced breast adenocarcinoma-induced tumor and increased lifespan.
保存条件：-20℃

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