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GW4869 促销  ≥98%

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包装规格：2mg 5mg 25mg 100mg in glass bottle
溶解性：溶于DMSO(5mg/mL )
产品描述：一种非竞争性的中性鞘磷脂酶（Smase)抑制剂,IC50为1 μM.GW4869 (dihydrochloride hydrate) is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase). GW4869 functions as an inhibitor, via a non-competitve manner. N-SMases are important in the metabolism of sphingomyelin producing ceramide and phosphocholine, which are important in cell signaling and regulation. Studies indicate that GW4869 can inhibit the activation of N-SMase by TNF-α in MC7 cells. As a result of this inhibition cell death and growth suppression are inhibited. Although GW4869 does not effect polymorphonuclear neutrophil (PMN) motility, it is useful with formylmethionylleucylphenylanaline (FMLP), since it inhibits PMN aggregation towards the chemotaxin.
保存条件：-20℃

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