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Nuvenzepine  ≥98%

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产品描述：基本信息 产品编号： N11356 产品名称： Nuvenzepine CAS: 96487-37-5   储存条件 粉末 -20℃ 四年     分子式： C19H20N4O2 溶于液体 -80℃ 6个月 分子量： 336.39 -20℃ 1个月 化学名：  11-(1-methylpiperidine-4-carbonyl)-6,11-dihydro-5H-benzo[b]pyrido[2,3-e][1,4]diazepin-5-one Solubility (25°C)：   体外:   DMSO   Ethanol   Water    体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 一种mAChR 的拮抗剂。 靶点 mAChR   体外研究 Nuvenzepine shows a four-fold higher affinity than pirenzepine in competitively antagonizing acetylcholine-induced contractions on isolated ileal musculature and on longitudinal ileum dispersed cells.Nuvenzepine is almost equipotent to pirenzepine in competitively preventing bethanechol-induced gall-bladder contractions and it displays a four-fold higher potency than pirenzepine in blocking vagal-stimulated tracheal constrictions. 体内研究 Intraduodenally administration of Nuvenzepine displays a long-lasting and dose-dependent inhibition of neostigmineinduced intestinal motility in anaesthetized cats.On ileal motor activity,Nuvenzepine shows a potency 10 times greater than that of pirenzepine.Nuvenzepine is also active,unlike pirenzepine,on colonic stimulated motility.Furthermore,in conscious cats,Nuvenzepine inhibits pentagastrin-stimulated gastric acid secretion resulting 25-30 times more potent than pirenzepine.Nuvenzepine has been found to be very active in inhibiting gastric acid secretion and intestinal hypermotility in rats,with very slight atropine-like side effects.The oral absorption rate is relatively slow,that the absolute bioavailability is 30 to 40%,that the elimination rate is slow and there is no accumulation in the body,and that there is very little metabolism.
保存条件：-20℃

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