生物试剂
>
生化试剂
>
信号通路
> 奥达特罗盐酸盐
加入收藏 取消收藏

奥达特罗盐酸盐  98%

促销价¥{{model.attbuying.price}}

市场价¥0.00

累计销量0 累计评价0 人评论

别称 {{model.alias}}
中文名称 {{model.name}}
英文名称 {{model.enname}}
品牌 {{model.brand}}
CAS {{model.cas}}
分子式
分子量 {{model.molecularweight}}
MDL {{model.mdl}}
货号 {{model.procode}}
数量

+ -

件 库存{{model.attbuying.number}}件
立即购买 加入购物车 下载说明书

看了又看
包装规格：5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于水(250mg/mL超声）
产品描述：基本信息 产品编号： O70041 产品名称： Olodaterol hydrochloride CAS: 869477-96-3   储存条件 粉末 -20℃ 四年     分子式： C21H27ClN2O5 溶于液体 -80℃ 6个月 分子量： 422.90 -20℃ 1个月 化学名：  (R)-6-hydroxy-8-(1-hydroxy-2-((1-(4-methoxyphenyl)-2-methylpropan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride Solubility (25°C)：   体外:   DMSO 85mg/mL (200.99mM) Ethanol 85mg/mL (200.99mM) Water 85mg/mL (200.99mM) 体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.3646mL 11.8231mL 23.6463mL 5mM 0.4729mL 2.3646mL 4.7293mL 10mM 0.2365mL 1.1823mL 2.3646mL 50mM 0.0473mL 0.2365mL 0.4729mL   生物活性 产品描述 一种选择性、长效的 β2-adrenoceptor (β2-AR) 激动剂。 靶点 β2 adrenoceptor 0.1nM (EC50)   体外研究 Olodaterol hydrochloride (0.1~10nM;fibroblasts) interferes with FGF-induced phosphorylation of signalling cascades.Olodaterol hydrochloride (0.001~10nM;fibroblasts) attenuates growth factor-induced motility and proliferation.Olodaterol hydrochloride (0.001~1000nM;0.5 hours;fibroblasts) increases intracellular cAMP in a concentration-dependent manner.Olodaterol hydrochloride (0~10nM;0.5 hours;fibroblasts) concentration-dependently inhibits the PICP increase with maximal efficacy of 70% at 10nM.Olodaterol hydrochloride has a subnanomolar affinity for the β2-AR (pKi=9.14) and is selective for this receptorin comparison with the β1-AR and β3-AR subtypes. Western Blot Analysis Cell Line: Fibroblasts Concentration: 0.1~10nM Result: Interfered with FGF-induced phosphorylation of signalling cascades. Cell Proliferation Assay Cell Line: Fibroblasts Concentration: 0.001~10nM Result: Attenuated growth factor-induced motility and proliferation. 体内研究 Olodaterol (1mg/kg;inhal;21 days) accelerats body weights recovery back to control levels (at day 21) and attenuats TGFβ-induced lung fibrosis.Olodaterol (0.1~3μg/kg;inhal;5 hours) induces a dose-dependent bronchoprotection.Olodaterol (0.3 and 0.6μg/kg;inhal;24 hours) induces a maximal bronchoprotection of approximately 60% after 0.5 hours. Animal Model: Lung fibrosis C57BL/6 mice Dosage: 1mg/mL Administration: Inhal;21 days Result: Accelerated body weight recovery back to control levels (at day 21) and attenuated TGF-βinduced lung fibrosis.   Animal Model: Guinea Pigs Dosage: 0.1~3μg/kg Administration: Inhal;5 hours Result: Induced a dose-dependent bronchoprotection.   Animal Model: Dogs Dosage: 0.3 and 0.6μg/kg Administration: Inhal;24 hours Result: Olodaterol (0.6μg/kg) induced a maximal bronchoprotection of approximately 60 % after 0.5h.
保存条件：-20℃

猜你喜欢