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SUN11602  ≥98%

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包装规格：5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO（≥37mg/mL）
产品描述：基本信息 产品编号：S11104 产品名称：SUN11602 CAS: 704869-38-5   储存条件 粉末 -20℃ 四年 分子式： C26H37N5O2 溶于液体 -80℃ 两年 分子量 451.60     化学名：      Solubility (25°C)   体外 DMSO 90mg/mL warmed with 50ºC water bath (199.29mM)   Ethanol 31mg/mL warmed with 50ºC water bath (68.64mM)   Water Insoluble 体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.2143mL 11.0717mL 22.1435mL 5mM 0.4429mL 2.2143mL 4.4287mL 10mM 0.2214mL 1.1072mL 2.2143mL 50mM 0.0443mL 0.2214mL 0.4429mL   生物活性 产品描述 一种新型的碱性苯胺化合物，具有成纤维细胞生长因子活性。 靶点/IC50 bFGF   体外研究 SUN11602 prevents glutamate-induced neuronal death in primary cultures of rat cerebrocortical neurons. SUN11602 increases the levels of CALB1 gene expression in cerebrocortical neurons.SUN11602 exerts protective effects on hippocampal neurons through activation of FGFR1 and increases CalB expression. SUN11602 promotes neurite outgrowth of primarily cultured rat hippocampal neurons. 体内研究 In WT mice, SUN11602 increases the levels of newly synthesized Calb in cerebrocortical neurons and suppresses the glutamate-induced rise in intracellular Ca2+. This Ca2+-capturing ability of Calb allows the neurons to survive severe toxic conditions of glutamate. Oral administration of SUN11602 at the midpoint of Aβ1-40 and ibotenate injections attenuate short-term memory impairment in the Y-maze test, as well as spatial learning deficits in the water maze task. In addition, the SUN11602 treatment inhibits the increase of peripheral-type benzodiazepine-binding sites (PTBBS),which are a marker for gliosis.   推荐实验方法(仅供参考) 细胞实验:   Cerebrocortical neurons are pretreated with vehicle (Hanks’Balanced Salt Solution),SUN11602,bFGF, or the other growth factors for 24h prior to the onset of glutamate toxicity.Subsequently,10μL of the MTT solution (5mg/mL) is added to each well (200μL of culture medium) of the microplates. Neurons in each well are then dried for 24h, and 200μL of DMSO is poured into all of the wells in order to dissolve the reaction products thoroughly for the MTT assay.   动物实验:   Rats: SUN11602 (0.1,1,and10mg/kg)is administered orally to the rat hippocampal-lesion model,once at 24h after the A β1–40 injection. In the vehicle-treated groups, saline is administered instead of SUN11602.
保存条件：-20℃

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