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Compound 48/80 trihydrochloride  ≥98%

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包装规格：50mg in glass bottle
溶解性：溶于DMSO(25mg/mL超声)和水(50mg/mL)
产品描述：基本信息 产品编号： C11246 产品名称： Compound 48/80 trihydrochloride CAS: 848035-21-2   储存条件 粉末 -20℃ 四年     分子式： C32H48Cl3N3O3 溶于液体 -80℃ 六个月 分子量 629.10 -20℃ 一个月 化学名：  2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-N-methylethanamine;trihydrochloride Solubility (25°C)：   体外:   DMSO 25mg/mL(39.74mM;Need ultrasonic) Ethanol   Water 25mg/mL(39.74mM;Need ultrasonic) 体内(现配现用): 1.请依序添加每种溶剂：10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility:≥2.5mg/mL(3.97mM);Clear solution 此⽅案可获得≥2.5mg/mL(3.97mM，饱和度未知)的澄清溶液。以1mL⼯作液为例，取100μL25.0mg/mL的澄清DMSO储备液加到400μL PEG300中，混合均匀；向上述体系中加⼊50μL Tween-80，混合均匀；然后继续加⼊450μL⽣理盐⽔定容⾄1mL。 2.请依序添加每种溶剂：10% DMSO→90% (20% SBE-β-CD in saline) Solubility:≥2.5mg/mL(3.97mM);Clear solution 此⽅案可获得≥2.5mg/mL(3.97mM，饱和度未知)的澄清溶液。以1mL⼯作液为例，取100μL25.0mg/mL的澄清DMSO储备液加到900μL20%的SBE-β-CD⽣理盐⽔⽔溶液中，混合均匀。 ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 1.5896mL 7.9479mL 15.8957mL 5mM 0.3179mL 1.5896mL 3.1791mL 10mM 0.1590mL 0.7948mL 1.5896mL   生物活性 产品描述 一种N-甲基对甲氧基苯乙胺与甲醛缩合产物的混合物。Compound 48/80 trihydrochloride也是一种组胺(histamine)释放剂和肥大细胞(mast cell)脱颗粒剂。Compound 48/80 trihydrochloride抑制人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性。 体外研究 Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositolspecific phospholipase C activities with a similar efficiency; IC50 values are 2.1μg/ml (supernatant) and 5.0μg/ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80 体内研究 Compound 48/80 trihydrochloride (0.75mg/kg; i.p.; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter. Compound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation Animal Model: 7-week-old Wistar male rats (fasted for 24 hours) Dosage: 0.75mg/kg Administration: Intraperitoneal injection; Killed after 0.5, 3 or 6 h Result: Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin concentrations in rats decreased time-dependently thereafter.
保存条件：-20℃

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