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YS-201  ≥98%

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包装规格：1mg in glass bottle
产品描述：基本信息 产品编号： Y10040 产品名称： YS-201 CAS: 108852-42-2   储存条件 粉末 -20℃ 四年     分子式： C24H31N3O6 溶于液体 -80℃ 6个月 分子量： 457.52 -20℃ 1个月 化学名：  3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,3-ethyl 5-[2-(1-piperidinyl)ethyl] ester Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   生物活性 产品描述 二氢吡啶类钙通道(calciumchannel)拮抗剂，有潜力用于心绞痛和高血压的研究。 靶点 Calcium Channel 体内研究 YS-201 (Diperdipine) markedly reduces systemic vascular resistance and improves stroke index and left ventricular ejection fraction.Mean pulmonary artery and wedge pressures are slightly increased as a possible consequence of enhanced venous return,whereas right atrial and left ventricular end-diastolic pressures are not significantly changed.Nevertheless,an increase in preload is clearly indicated by an augmented left ventricular end-diastolic volume index after administration of diperdipine.After intravenous and oral doses,absolute bioavailability is calculated to be 18.7%.Biliaryexcretion accounts for about 0.1% of the total clearance of diperdipine and does not contribute to the overall elimination of the drug.After intraportal administration,the bioavailable fraction of diperdipine is increasing up to 44.3% suggesting a prehepatic site of loss of the drug.The single application of diperdipine to mice and rats by gavage causes intolerance reactions starting at the lowest tested dose level of 200 mg/kg b.w.p.o.(mice) and at 250mg/kg b.w.p.o.(rats).In the rat,toxic effects occur from 15mg diperdipine/kg b.w./day p.o. onwards.
保存条件：-20℃

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