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洛度沙胺氨丁三醇  ≥98%

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包装规格：1g in glass bottle
溶解性：溶于DMSO（20mg/mL超声）
产品描述：基本信息 产品编号： L10458  产品名称： Lodoxamide tromethamine CAS: 63610-09-3   储存条件 粉末 2-8℃ 四年     分子式： C15H17ClN4O9 溶于液体 -80℃ 6个月 分子量： 553.90 -20℃ 1个月 化学名：  N,N'-(2-Chloro-5-cyano-m-phenylene)dioxamic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:2) Solubility (25°C)：   体外:   DMSO Insoluble Ethanol Insoluble Water 19mg/mL (34.3mM) 体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 1.8054mL 9.0269mL 18.0538mL 5mM 0.3611mL 1.8054mL 3.6108mL 10mM 0.1805mL 0.9027mL 1.8054mL 生物活性 产品描述 作为肥大细胞稳定剂的抗过敏化合物, 用于研究哮喘和过敏性结膜炎。 靶点 Histamine Receptor   体外研究 lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced 45Ca influx with associated histamine release in purified rat peritoneal mast cells. 体内研究 Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model3 and in Ascaris antigen-sensitized rhesus monkeys.When given intravenously,orally,or intrabronchially by aerosol,lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized.anesthetized rhesus monkeys.Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation,decreased microvascular permeability,and increased compliance.Patients treated with lodoxamide tromethamine demonstrate an improvement in daytime breathing difficulty,cough,sputum production,and sleep.
保存条件：2-8℃

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