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盐酸吡哌咯生  ≥98%

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包装规格：1mg 5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO（≥31mg/mL）
产品描述：基本信息 产品编号： P10981  产品名称： Piperoxan hydrochloride CAS: 135-87-5   储存条件 粉末 -20℃ 四年     分子式： C14H20ClNO2 溶于液体 -80℃ 6个月 分子量： 269.77 -20℃ 1个月 化学名：  Piperidine,1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-,hydrochloride (1:1) Solubility (25°C)：   体外:   DMSO 54mg/mL (200.17mM) Ethanol 40mg/mL (148.27mM) Water 54mg/mL (200.17mM) 体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.7069mL 18.5343mL 37.0686mL 5mM 0.7414mL 3.7069mL 7.4137mL 10mM 0.3707mL 1.8534mL 3.7069mL 50mM 0.0741mL 0.3707mL 0.7414mL   生物活性 产品描述 一种 α2 肾上腺素受体拮抗剂。 靶点 adrenoceptor   体外研究 When the medulla is superfused with α2 adrenoceptor antagonist Piperoxane (50μM;5 min) while the pons is with artificial cerebrospinal fluid (ACSF),the three inactive preparations display rhythmic phrenic bursts at a low frequency (2-4 c/min),and the phrenic burst frequency of the 12 active ones significantly increases during the last 3 min of Piperoxane applications (163±12% of the previous mean frequency).In active medullary preparations, the effects of NA applications (25μM;5 min) are compared when the preparations sre superfused either by ACSF (n=8) or by the α2 adrenoceptor antagonist Piperoxane (50μM;PIP-ACSF;n=5).NA applications either alone (NA-ACSF) or with Piperoxane (PIP-ACSF+NA) significantly increases the phrenic burst frequency.However,the blockage of the medullary α2 adrenoceptors by Piperoxane potentiates a phrenic burst frequency increase:during the fifth minute of NA applications,the phrenic burst frequency reached 171±11% of the mean control value when ACSF is applied alone and 234±21% of the mean control value when PIP-ACSF is applied in control condition.   推荐实验方法(仅供参考) 激酶实验： The mouse neonates (P0-P3) are ether-anesthetized and decerebrated;the brain stems and the cervical spinal cords are dissected out and placed ventral sides up in a 2mL chamber superfused with artificial cerebrospinal fluid (ACSF) at 27±0.25℃ (mean±SD),renewed at a rate of 2mL/min.The ACSF [containing (in mM) 129 NaCl,3.35 KCl,1.26 CaCl2,1.15MgCl 2,21 NaHCO3,0.58 NaH2PO4,and 30 glucose] is oxygenated and equilibrated (pH 7.4 at 27℃) by bubbling carbogene (95% O 2-5% CO2).In the pharmacological experiments,this is replaced by another ACSF in which bioreactive substances are dissolved:noradrenaline at 25μM (NA-ACSF) or α2 adrenoceptor antagonists,either Piperoxane at 50μM (PIP-ACSF) or yohimbine at 50μM (YO-ACSF).In some of the experiments,a patch-clamp microelectrode (1μm diameter tip) is lowered within the ventral pons into the A5 nucleus where a solution of either ACSF or NA (1mM) is pressure-ejected.The ejected volume is estimated 20nL for a pressure pulse lasting 2s.   动物实验:   Mice Male Balb-C mice are used, weighing between 20 and 25g.In mice pretreated with the α-adrenoceptor antagonist Piperoxan,or with naloxone,both at a dose of 3×10-5 mol /kg s.c.given 15 min before the acetic acid,the antinociceptive action of (-)-isoprenaline is only slightly antagonized.Dose-ratios of 1.45 and 1.7,are produced by these two antagonists.
保存条件：-20℃

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