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包装规格：1g 5g 25g in glass bottle
溶解性：溶于DMSO（≥ 35 mg/mL）
产品描述：基本信息 产品编号： N60014  产品名称： Nicardipine hydrochloride CAS: 54527-84-3   储存条件 粉末 2-8℃ 四年 分子式： C26H30ClN3O6 溶于液体 -80℃(避光) 6个月 分子量： 515.99 -20℃(避光) 1个月 化学名：  3-{2-[benzyl(methyl)amino]ethyl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride Solubility (25°C)：   体外:   DMSO 100mg/mL (193.8mM) Ethanol Insoluble Water Insoluble 体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 1.9380mL 9.6901mL 19.3802mL 5mM 0.3876mL 1.9380mL 3.8760mL 10mM 0.1938mL 0.9690mL 1.9380mL   生物活性 产品描述 一种钙通道(calcium channel)阻滞剂，可阻断心脏钙通道，IC50为1μM。Nicardipine hydrochloride可用于研究慢性心绞痛以及控制血压。 靶点 IC50:1μM (cardiac calcium channels)   体外研究 Nicardipine (0.1-10μM;24-48h) reduces viability and proliferation of vascular smooth muscle cells (VSMCs) and inhibits their ability to migrate. Cell Viability Assay Cell Line: VSMCs were isolated from New Zealand rabbit aortic preparations Concentration: 0.1μM,1μM,3μM,10μM Incubation Time: 24-48 hours Result: Treatment reduced significantly cell viability and inhibited VSMCs proliferation in the presence of 10% FBS in a dose-dependent way,from 205.4±17.5% to 176.6±17%,160.6±5.7%,150.4±11.2%,61.22±7.83% after 0.1μM,1μM,3μM,10μM treatment, respectively. Western Blot Analysis Cell Line: BV-2 microglial cells Concentration: 1,3,5,10μM Incubation Time: 1 hours Result: Reduced LPS/IFN-γ- and peptidoglycan-induced iNOS expression and COX-2 expression in a concentration-dependent manners. 体内研究 Nicardipine (0.3-10mg/kg;p.o.) shows antihypertensive properties.LD50s of Nicardipine are 643mg/kg (oral) and 557mg/kg (oral);18.1mg/kg (intravenous) 25.0mg/kg (intravenous);735mg/kg (subcutaneous) and 683mg/kg (subcutaneous);171mg/kg (intraperitoneally) and 155mg/kg (intraperitoneally) for male and female Sprague-Dawley rats,respectively.LD50s of Nicardipine are 187mg/kg (oral) and 15.5mg/kg (intravenous) for male Wistar rats,respectively.LD50s of Nicardipine are 634mg/kg (oral) and 650mg/kg (oral);20.7mg/kg (intravenous) 19.9mg/kg (intravenous);540mg/kg (subcutaneous) and 710mg/kg (subcutaneous);144mg/kg (intraperitoneally) and 161mg/kg (intraperitoneally) for male and female mice,respectively. Animal Model: In conscious normotensive rats (NR) Dosage: 0.3-10mg/kg Administration: P.o. Result: Induced a dose-dependent hypotensive response (maximal decrease in mean blood pressure, supine position) without any postural hypotensive response.
保存条件：2-8℃

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