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Piclidenoson  ≥98%(HPLC)

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包装规格：5mg 10mg 25mg 50mg in glass bottle
溶解性：溶于DMSO(＞5mg/mL)和乙醇(＞10mg/mL 加热）。
产品描述：基本信息 产品编号： P10152 产品名称： b-D-Ribofuranuronamide,1-deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl- CAS: 152918-18-8   储存条件 粉末 -20℃ 四年     分子式： C18H19In6O4 溶于液体 -80℃ 6个月 分子量： 510.28 -20℃ 1个月 化学名：  (2S,3S,4R,5R)-3,4-dihydroxy-5-(6-((3-iodobenzyl)amino)-9H-purin-9-yl)-N-methyltetrahydrofuran-2-carboxamide Solubility (25°C)：   体外:   DMSO   Ethanol   Water   体内(现配现用):   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 1.9597mL 9.7983mL 19.5967mL 5mM 0.3919mL 1.9597mL 3.9193mL 10mM 0.1960mL 0.9798mL 1.9597mL   生物活性 产品描述 一种腺苷A3受体激动剂, EC50值为0.11μM。 靶点 A3AR   体外研究 Piclidenoson is able to inhibit Forskolin (HY-15371)-stimulated cAMP levels with EC50s of 0.82μM and 1.2μM in OVCAR-3 cells and Caov-4 cells,respectively.Piclidenoson (0.0001-100μM;48 hours) significantly reduces cell viability in a dose-dependent manner in human ovarian cancer cell lines,with IC50s of 32.14μM and 45.37μM for OVCAR-3 and Caov-4 cells,respectively.Piclidenoson (0.001-100μM;48 hours) induces apoptosis in ovarian cancer cell line through the caspase pathway.Piclidenoson induces apoptosis via the mitochondrial signaling pathway. Cell Proliferation Assay Cell Line: OVCAR-3 cells,Caov-4 cells Concentration: Concentration:0.0001-100μM Incubation Time: 48 hours Result: Resulted in a dose-dependent reduction in the cell viability. Apoptosis Analysis Cell Line: OVCAR-3 cells, Caov-4 cells Concentration: 0.1μM,1μM,10μM,50μM,100μM Incubation Time: 48 hours Result: Significant increased in the percentage of apoptosis in a concentration-dependent manner. Western Blot Analysis Cell Line: OVCAR-3 cells, Caov-4 cells Concentration: 1μM,10μM,100μM Incubation Time: 48 hours Result: Decreased the expression of Bcl-2 was noticeably and increased the expression of Bax protein. 体内研究 Piclidenoson (105μg/kg;i.p.) enhances survival of γ-irradiated mice. Animal Model: B10CBAF1 male mice aged 3 months (average 30g) Dosage: 105μg/kg Administration: Intraperitoneal injection, 0.5h after irradiation Result: Resulted in statistically significant increases of the mean survival time in comparison with the control irradiated mice.
保存条件：-20℃

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