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FX1  ≥98%（HPLC）

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包装规格：5mg 25mg 100mg in glass bottle
溶解性：溶于DMSO(73mg/mL)
产品描述：一种BCL6抑制剂，IC50：35μM。 FX1 is an inhibitor of the B cell lymphoma 6 (BCL6). FX1 has 10-fold greater potency than endogenous corepressors and binds an essential region of the BCL6 lateral groove. FX1 disrupted formation of the BCL6 repression complex, reactivated BCL6 target genes, and mimicked the phenotype of mice engineered to express BCL6 with corepressor binding site mutations. Low doses of FX1 induced regression of established tumors in mice bearing DLBCL xenografts. Furthermore, FX1 suppressed ABC-DLBCL cells in vitro and in vivo, as well as primary human ABC-DLBCL specimens ex vivo。
保存条件：-20℃

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