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SB-200646A 促销  ≥98%

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包装规格：50mg in glass bottle
产品简介：是第一个对 5-HT2B/2C的选择性超过 5-HT2A 的拮抗剂，5-HT2B，5-HT2C 和 5-HT2A 的 pKi 值分别为7.5、6.9 和 5.2。SB-200646A 具有口服活性，在体内具有电生理和抗焦虑特性。
溶解性：溶于DMSO（250mg/mL 超声）
储备液保存：-80°C, 6 months; -20°C, 1 month。 (sealed storage, away from moisture)
靶点：5-HT2B Receptor:7.5 (pKi);5-HT2A Receptor;5-HT2B Receptor;5-HT2C Receptor; 5-HT2C Receptor:6.9 (pKi);5-HT2A Receptor:5.2 (pKi)
体外研究：SB200646A (4 μM) abolishes the ethanol-induced increase in miniature inhibitory postsynaptic current (mIPSC) frequency and had no effect on basal mIPSC frequency.
体内研究：SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area(VTA) dopaminergic neurons. The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons.
动物实验：Animal Model: Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350g at the time of the experiment) Dosage:20 mg/kg Administration:Intravenous injection; daily; for 21 days. Result:Significantly decreased the number of spontaneously active ventral tegmental area (VTA)dopaminergic neurons.
保存条件：-20℃
注意事项：1、为了您的安全和健康，请穿实验服并戴一次性手套操作。 2、以上信息仅做参考交流之用。

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