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LQZ-7I  ≥98%

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包装规格：5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO（125 mg/mL 超声）
产品描述：基本信息 产品编号：L10347 产品名称：LQZ-7I CAS: 195822-23-2   储存条件 粉末 -20℃ 四年     分子式： C20H14F2N4 溶于液体 -80℃ 六个月 分子量 348.35 -20℃ 一个月 化学名：      Solubility (25°C)   体外 DMSO 70mg/mL (200.94mM) Ethanol 70mg/mL (200.94mM) Water Insoluble 体内（现配现用）     ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.8707mL 14.3534mL 28.7068mL 5mM 0.5741mL 2.8707mL 5.7414mL 10mM 0.2871mL 1.4353mL 2.8707mL 50mM 0.0574mL 0.2871mL 0.5741mL   生物活性 产品描述 一种靶向 survivin 的抑制剂。LQZ-7I 抑制生存素二聚化。LQZ-7I 口服有效抑制异种移植肿瘤生长并诱导肿瘤中生存素的损失。 靶点/IC50 survivin(in PC-3 Cells) survivin(in C4-2 Cells) 4.8µM(ic50) 3.1µM(ic50) 体外研究 LQZ-7I has improved cytotoxicity with IC50s of 3.1µM against C4-2 cells and 4.8µM against PC-3 cells compared with the parent compound LQZ-7.LQZ-7I (10µM; 0-6 hours) treatment reduces the expression of survivin. However, LQZ-7I does not reduce the expression of XIAP, CIAP1, and CIAP2. LQZ-7I may be selective to its intended target survivin. Western Blot Analysis Cell Line: PC-3 or C4-2 cells Concentration: 10µM Incubation Time: 0-6 hours Result: Reduced the expression of survivin. 体内研究 LQZ-7I (100mg/kg; oral gavage every other day for a total of ten treatments) significantly suppresses tumor growth without any notable adverse effect on the mice. Animal Model: 6-week old male NSG mice Dosage: 100mg/kg; 200µL vehicle (90% corn oil/10% DMSO) Administration: Oral gavage every other day for a total of ten treatments Result: Significantly suppressed tumor growth without any notable adverse effect on the mice as indicated by lacking changes in body weight and in wet weight of major organs at the end of the study.
保存条件：-20℃

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