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吡罗达韦  ≥98%

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溶解性：溶于DMSO（10 mg/mL 超声)
产品描述：基本信息 产品编号：P10613 产品名称：Pirodavir CAS: 124436-59-5   储存条件 粉末 -20℃ 四年     分子式： C21H27N3O3 溶于液体 -80℃ 六个月 分子量 369.46 -20℃ 一个月 化学名：  ethyl 4-(2-(1-(6-methylpyridazin-3-yl)piperidin-4-yl)ethoxy)benzoate   Solubility (25°C)   体外 DMSO 10 mg/mL (27.07mM; Need ultrasonic) Ethanol    Water   体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.7067mL 13.5333mL 27.0665mL 5mM 0.5413mL 2.7067mL 5.4133mL 10mM 0.2707mL 1.3533mL 2.7067mL   生物活性 产品描述 一种有效的小核糖核酸病毒抑制剂，高效作用于 A 和 B 型鼻病毒。 靶点/IC50 Rhinovirus   体外研究 Pirodavir is a potent, broad-spectrum picornavirus inhibitor. Pirodavir inhibits 80 of the 100 human rhinovirus (HRV) strains tested at a concentration of 64ng/mL. In that same study, Pirodavir is also effective in inhibiting 16 enteroviruses, with a mean 80% inhibitory concentration (IC80) of 1,300ng/mL. Pirodavir inhibits enterovirus 71 replication with an IC50 of 5,420nM and an IC90 of >13,350nM. Pirodavir inhibits 56 rhinovirus laboratory strains and three of the clinical isolates tested. Pirodavir inhibits 59% of the serotypes and isolates with IC50s of <100nM. Pirodavir concentrations of 16 and 4μg/mL reduces cell growth by 66% (s.e.m. 0.75) and 28% (s.e.m. 0.25), respectively. Lower concentrations (1μg/mL) of Pirodavir are not inhibitory for cell growth. The 50% cytotoxic concentration of pirodavir for logarithmic cell growth at 37°C is 7μg/mL.Under the conditions of the antiviral assay (confluent HeLa cells at 33°C), the 50% cytotoxic concentration is >50μg/mL.   推荐实验方法(仅供参考) 细胞实验:   Cell Assay HeLa cells are seeded at a concentration of approximately 180,000 cells per dish in six-well plates containing 4mL of growth medium. Growth medium consist of Eagle's basal medium, supplemented with 5% fetal calf serum, 2% sodium bicarbonate,and 1% glutamine. After 24 h of incubation at 37°C in a humidified CO2 atmosphere, the growth medium is removed and replaced by the test solutions (fresh growth medium with or without various concentrations of the antiviral compounds). To assess the cytotoxicity of the antiviral compounds (e.g., Pirodavir), the number of living cells are determined present in triplicate cultures at the time of Pirodavir addition and every 24 h for 3 days. Following trypsinization, the number of viable cells for each drug concentration is counted in triplicate with a Coulter Counter.
保存条件：-20℃

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