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MN-64  ≥98%(HPLC)

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包装规格：5mg 10mg 25mg 50mg 100mg in glass bottle
溶解性：溶于DMSO(100mg/mL 超声)
产品描述：基本信息 产品编号：M10332 产品名称：MN-64 CAS: 92831-11-3   储存条件 粉末 -20℃ 四年     分子式： C18H16O2 溶于液体 -80℃ 两年 分子量 264.32 -20℃ 一个月 化学名：  2-(4-Isopropylpheny)-4H-chroMen-4-one   Solubility (25°C)   体外 DMSO 53mg/mL (200.51mM) Ethanol 53mg/mL (200.51mM) Water Insoluble 体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 3.7833mL 18.9165mL 37.8329mL 5mM 0.7567mL 3.7833mL 7.5666mL 10mM 0.3783mL 1.8916mL 3.7833mL 50mM 0.0757mL 0.3783mL 0.7567mL   生物活性 产品描述 一种高效的选择性的Tankyrase 1和2抑制剂，IC50分别为6和72nm。 靶点/IC50 TNKS1 6nM (IC50) TNKS1 6nM (IC50) ARTD1 19.1μM (IC50) ARTD2 39.4μM (IC50)   体外研究 MN-64 is a potent tankyrase 1 inhibitor, with IC50s of 6nM, 72nM, 19.1μM, 39.4μM for TNKS1, TNKS2, ARTD1 and ARTD2, respectively. MN-64 effectively inhibits Wnt/β-catenin at 1μM, and blocks STF luciferase activity at 200nM.   推荐实验方法(仅供参考) 激酶实验： Kinase Assay Inhibitory potency of compounds on Tankyrase-1 enzymatic activity is evaluated using a Scintillation Proximity Assay (SPA). The assay is designed to measure compound inhibition of Tankyrase-1 autoPARsylation (Tankyrase-1 is both enzyme and substrate in this assay). Truncated recombinant human Tankyrase-1 protein (amino acids E1023-T1327) is purified from SF9 cells. The assay is conducted using 0.11μM of Tankyrase-1 protein and 3μM nicotinamide adenine dinucleotide (NAD+ , 2.12μM 3H-NAD+  with a specific radioactivity of 1690 Ci/mol, 0.88 μM biotin- NAD+), in pH 7.5 Tris buffer (60mM Tris, 1mM DTT, 0.01% (v/v) Tween-20®, 2.5mM MgCl2, 0.3mg/mL BSA). For IC50 determination, 10mM DMSO stock solution of a compound (MN-64) is sequentially diluted by two-fold in DMSO, and aliquots of the diluted solutions are transferred to 384-well assay plates and mixed with Tankyrase-1 solution.
保存条件：-20℃

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