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Sulfosuccinimidyl oleate sodium  ≥98%

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包装规格：5mg 10mg 25mg 50mg in glass bottle
溶解性：溶于DMSO（62.5 mg/mL 超声）
产品描述：基本信息 产品编号：S10763 产品名称：Sulfosuccinimidyl oleate sodium CAS: 1047644-62-1   储存条件 粉末 -20℃ 四年 分子式： C22H36NNaO7S 溶于液体 -80℃ 六个月 分子量 481.58 -20℃ 一个月 化学名：      Solubility (25°C)   体外 DMSO 50mg/mL (103.82mM; Need ultrasonic) Ethanol   Water   体内 现配现用   ＜1mg/ml表示微溶或不溶。 普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。   制备储备液   浓度   溶液体积 质量   1mg   5mg   10mg 1mM 2.0765mL 10.3825mL 20.7650mL 5mM 0.4153mL 2.0765mL 4.1530mL 10mM 0.2076mL 1.0382mL 2.0765mL   生物活性 产品描述 一种长链脂肪酸，抑制脂肪酸向细胞转运。Sulfosuccinimidyl oleate sodium 是一种有效且不可逆的线粒体呼吸链抑制剂。Sulfosuccinimidyl oleate sodium 结合小胶质细胞表面上的 CD36 受体。具有抗炎作用。 靶点/IC50 Mitophagy   体外研究 Sulfosuccinimidyl oleate (20μM and 50μM, 24 hours) alone does not alter the cellular viability. Exposure to 100ng/ml LPS+5ng/mL IFNγ modestly, yet significantly reduces the viability of the BV2 cells. Co-treatment with Sulfosuccinimidyl oleate prevents the LPS+IFNγ-induced reduction in the cell viability. Sulfosuccinimidyl oleate (50μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50μM, 24 hours) Cell Viability Assay Cell Line: BV2 cells Concentration: 20μM and 50μM Incubation Time: 24 hours Result: Did not alter the viability of BV2 cells alone. Exposure of BV2 cells to 100ng/mL LPS and 5ng/mL IFNγ significantly reduced the viability of BV2 cells while simultaneous treatment with Sulfosuccinimidyl oleate prevented it. Western Blot Analysis Cell Line: BV2 cells Concentration: 50μM Incubation Time: 24 hours Result: Drastically increased the levels of NOS2, COX-2, and P-p38/T-p38.   体内研究 Sulfosuccinimidyl oleate (50mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls in male BALB/cABom mice with pMCAo model. In addition,Sulfosuccinimidyl oleate at 50mg/kg is suitable to see a beneficial effect after stroke. Animal Model: 4-month-old male BALB/cABom mice with pMCAo model Dosage: 50mg/kg Administration: Administered once by single oral gavage Result: Reduced brain damage following ischemia. Attenuated infarct size.
保存条件：-20℃

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